Levorphanol: Rewinding an old, bygone multimodal opioid analgesic!
نویسندگان
چکیده
منابع مشابه
Levorphanol: Revisiting an Underutilized Analgesic
Levorphanol (levo-3-hydroxy-N-methylmorphinan) is a step 3 opioid first developed in the 1940s as an alternative to morphine. Levorphanol belongs to the morphinan opioid series. Levorphanol has greater potency than morphine and is a potent N-methyl-d aspartate (NMDA) antagonist. Levorphanol interferes with the uptake of norepinephrine and serotonin, which makes it potentially useful for neuropa...
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Levorphanol, termed “the forgotten opioid,” is a potent opioid analgesic available for the treatment of moderate to severe pain. It was first approved in 1953, and it has a wide range of ascending and descending pain pathway receptor-mediated pharmacological activities, including mu, delta, and kappa (kappa 1 and 3) opioid agonism; N-methyl-D-aspartate (NMDA) antagonism; and reuptake inhibition...
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Levorphanol is a potent opioid analgesic that was first approved for use in the United States in 1953. Levorphanol is approved for use in moderate to severe pain where an opioid analgesic is appropriate. Levorphanol has a wide range of activities including mu opioid agonism, delta agonism, kappa1 and kappa3 receptor agonism, N-methyl-d-aspartate receptor antagonism and reuptake inhibition of bo...
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Since the first cases of severe and fatal liver damage were reported in 1966,1,2 overdose of paracetamol has become the cause of 100–200 deaths in the UK each year.3 Paracetamol toxicity remains the leading cause of fulminant hepatic failure in the UK and is a common reason for liver transplantation.4,5 Knowledge of the toxic mechanism (Fig 1) has led to effective antidotes which provide substr...
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Acute postoperative pain in patients with opioid tolerance creates a significant management challenge for anesthesiologists and pain medicine physicians. A multimodal approach is key; however other factors can complicate management such as opioid induced hyperalgesia. We present the case of a patient on large amounts of intrathecal opioids for chronic pain syndrome with opioid induced hyperalge...
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ژورنال
عنوان ژورنال: Indian Journal of Palliative Care
سال: 2019
ISSN: 0973-1075
DOI: 10.4103/ijpc.ijpc_11_19